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A Cure for AIDS?

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Topic: A Cure for AIDS?
Posted By: Shub
Subject: A Cure for AIDS?
Date Posted: 29 June 2009 at 12:07am
http://www.baldwincountynow.com/articles/2009/05/28/local_news/doc4a1d63cb68531598814432.txt - Link



Replies:
Posted By: oreomann33
Date Posted: 29 June 2009 at 12:40am
Someone's been Digging.

I bet the cures slow progression into medicine has something to do with stem cells.


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Posted By: Shub
Date Posted: 29 June 2009 at 1:22am
Nope, it came across my twitter feed.


Posted By: Reb Cpl
Date Posted: 29 June 2009 at 2:07am
I don't buy much into conspiracy crap, but I strongly believe that this sort of thing has been possible for a long time, but doesn't get publicity or marketed for one of two reasons:

1. The cost to produce the drug, or undertake the procedure is so expensive that its availability isn't feasible, or

2. The rights to the drugs and or procedures are bought up by pharmaceutical companies who bury it in the hopes of marketing more expensive and less effective drugs/procedures.

I really don't think this is new technology.


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Posted By: Darur
Date Posted: 29 June 2009 at 2:26am
This was posted a while back.

I suspect the reason it isn't mainstream is due to a mix of things, including the inadvisability of nuking whats left of someone's immune system to kill a virus that . . . nukes your immune system.  There's also the difficulty of finding sources of bone marrow to match all the different people with HIV that ALSO has the appropriate gene attached to it.  Finding the bone marrow to match itself is tough enough statistically. 

It would be a very risky procedure, and a great way to bring about malpractice suits.





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Posted By: adrenalinejunky
Date Posted: 29 June 2009 at 2:41am
Originally posted by Reb Cpl Reb Cpl wrote:

I don't buy much into conspiracy crap, but I strongly believe that this sort of thing has been possible for a long time, but doesn't get publicity or marketed for one of two reasons:1. The cost to produce the drug, or undertake the procedure is so expensive that its availability isn't feasible, or2. The rights to the drugs and or procedures are bought up by pharmaceutical companies who bury it in the hopes of marketing more expensive and less effective drugs/procedures. I really don't think this is new technology.


doesn't really apply in this case as the cure isn't a drug, as darur alluded to its a complete bone marrow transplant - another article i read on it a while back stated that its normally only given to people with late stage cancer because the procedure kills approxamately 30% of the people who do it.

and as darur also said - you pretty much have to destroy the persons immune system to do it because the persons old bone marrow has to be completely destroyed, which they do with chemotherapy.

also bone marrow of the donor has to very closely match bone marrow of the recipient, as a result of which the majority of people on transplant lists die before they ever find a suitable donor.

add in the unlikelyhood of finding a suitable donor who is HIV immune and well... this isn't really a feasable widespread treatment.

it could be a very important discovery however, as they are currently looking at possible ways using gene therapy to cure aids based on this principal.


Posted By: Rambino
Date Posted: 29 June 2009 at 11:37am
Not getting attention?  This was all over the news when it was, you know, new.
 
There are several promising avenues for actual cures of HIV and other viral diseases out there, and this is one of them.  None are ready for prime time, but plenty of money is being thrown at anything with a prayer for success.
 


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Posted By: tallen702
Date Posted: 29 June 2009 at 11:45am
If I could jut in here for just a second. "No detectable virus count" and "Cured" aren't the same thing. All the CCR5 Delta32 gene does is prevent the virus' reproduction as rapidly as it would in a more favorable environment. The virus is still there, just in minute quantities. There's still a chance at spreading it. Does this particular genetic mutation mean you're going to live a long life that might otherwise be cut short by HIV/AIDS? Yes. Does it mean you are cured? No. And that's a very dangerous line that people seem to freely want to cross. Magic Johnson has a non-detectable viral load right now, but if he went out and started bonking people without protection, he'd still spread the disease. Maybe not as much, but he still would. In short, NOT A CURE, just a really really really good bandaid.

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Posted By: Rambino
Date Posted: 29 June 2009 at 2:08pm

Generally a good distinction, tallen.

In this case, however, it is my understanding at least that the thinking is that this CCR5 mutation actually allows the immune system to shake off HIV completely, just like the rest of us (eventually) shake off a cold.  When we are between colds, we have not simply suppressed virii, but kicked them out completely.  We are "cured" of that particular cold, and are not contagious at all.
 
Of course, we then get another cold shortly thereafter.
 
 
If this is how this CCR5 mutation works as well, then it would be a "cure" in every sense.
 


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Posted By: adrenalinejunky
Date Posted: 29 June 2009 at 2:39pm
from my reading on the subject it seems rambino is correct...

as the CCR5 mutation prevents AIDS from binding with white blood cells, they are unable to replicate and should all die off.

edit:

either way it is a cure for AIDS: or Acquired Imunno Deficiancy Syndrom, the question is whether it cures the underlying cause - or HIV, which as i said, from what i've read it appears that it should.


Posted By: Rofl_Mao
Date Posted: 29 June 2009 at 7:24pm



Posted By: Frozen Balls
Date Posted: 29 June 2009 at 7:32pm


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Posted By: GI JOES SON
Date Posted: 29 June 2009 at 7:47pm
dang,  beat me to the south park joke..


Posted By: Monk
Date Posted: 29 June 2009 at 7:47pm
FDA approval is going to be a pain.



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